HCID 11194588, compound → HCID 14851848, compound

Participants

Reaction Steps

Reaction of 6-(2-fluorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine with 2,3-dihydro-(2-propynyl)-1H-isoindol-1-one [ref. J. I. Neumeyer, U. V. Moyer, J. A. Richman, F. J. Rosenberg and D. G. Teiger, J. Med. Chem. 10, 615 (1967)] gave after chromatographic purification as described in example 17 and crystallization from ethyl acetate colorless crystals of the title compound with m.p. 165°-168° C. According to spectral and analytical data, these crystals contained 0.5 molar amounts of water and traces of ethyl acetate.

Provenance & Evidence