HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 4-(2-chlorophenyl)-2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine | HCID 14851924 | — |
| Reactant | 1-(2-propynyl)benz[cd]indol-2(1H)-one | HCID 14851940 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 14851860 | HCID 14851860 | — |
Reaction Steps
Reaction of 4-(2-chlorophenyl)-2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4] triazolo[4,3-a][1,4]diazepine with 1-(2-propynyl)-benz[cd]indol-2(1H)-one as described in Example 37 yielded after chromatographic purification and slow crystallization from ethyl acetate yellow crystals with m.p. 202°-205° C. These crystals contained according to analytical data 0.75 mol of water. Treatment of this product with ethanolic hydrogen chloride and addition of ethyl acetate gave a crystalline hydrochloride of the title compound with m.p. 219°-222° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04959361 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-6ef501d54554447cbc8cfc1417339939 |
| Source note | uspto-grants-1990_09 |