Hydrochloric Acid → Hydrochloric Acid

HRID 1032761Notes

Reaction equation

HRID 1032761 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16](I)[S:17][C:13]=2[N:12]2[C:19]([CH3:22])=[N:20][N:21]=[C:11]2[CH2:10][N:9]=1.[CH2:23]([N:26]1[C:34]2[C:29]3[C:30](=[CH:35][CH:36]=[CH:37][C:28]=3[C:27]1=[O:38])[CH:31]=[CH:32][CH:33]=2)[C:24]#[CH:25].O.Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:25]#[C:24][CH2:23][N:26]3[C:34]4[C:29]5[C:30](=[CH:35][CH:36]=[CH:37][C:28]=5[C:27]3=[O:38])[CH:31]=[CH:32][CH:33]=4)[S:17][C:13]=2[N:12]2[C:19]([CH3:22])=[N:20][N:21]=[C:11]2[CH2:10][N:9]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 148519244-(2-chlorophenyl)-2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepineHCID 148519401-(2-propynyl)benz[cd]indol-2(1H)-one

Product 2

HCID 313Hydrochloric AcidHCID 14851860HCID 14851860, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Reaction of 4-(2-chlorophenyl)-2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4] triazolo[4,3-a][1,4]diazepine with 1-(2-propynyl)-benz[cd]indol-2(1H)-one as described in Example 37 yielded after chromatographic purification and slow crystallization from ethyl acetate yellow crystals with m.p. 202°-205° C. These crystals contained according to analytical data 0.75 mol of water. Treatment of this product with ethanolic hydrogen chloride and addition of ethyl acetate gave a crystalline hydrochloride of the title compound with m.p. 219°-222° C.

Workup

  1. customyielded
  2. customafter chromatographic purification and slow crystallization from ethyl acetate yellow crystals with m.p. 202°-205° C

Sources & evidence

ORD record
ord-6ef501d54554447cbc8cfc1417339939
Source dataset
uspto-grants-1990_09
Patent number
US04959361

Reaction notes

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