Ethanol → HCID 14851929, compound

HRID 1032797Notes

Reaction equation

HRID 1032797 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16](I)[S:17][C:13]=2[N:12]2[C:19]([CH3:22])=[N:20][N:21]=[C:11]2[CH:10]([CH3:23])[N:9]=1.[CH2:24]([N:27]1[C:40](=[O:41])[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[C:33]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]1=2)[C:25]#[CH:26].C(O)C>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:26]#[C:25][CH2:24][N:27]3[C:40](=[O:41])[C:39]4[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=4)[C:33]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]3=4)[S:17][C:13]=2[N:12]2[C:19]([CH3:22])=[N:20][N:21]=[C:11]2[CH:10]([CH3:23])[N:9]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 14851914HCID 14851914, compoundHCID 14894694HCID 14894694, compound

Product 1

HCID 14851929HCID 14851929, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This compound was prepared by reacting rac-4-(2-chloro-phenyl)-2-iodo-6,9-dimethyl-6H-thieno-[3,2-f][1,2,4]triazolo[4,3a][4,1]diazepine (from example 108) with 5-(2-propynyl)-6(5H) phenanthridinone under the conditions described in example 37. The product was isolated by chromatography over the 50 -fold amount of silica gel using 5% (v/v) of ethanol in methylene chloride. The product was crystallized from ethanol to give yellowish crystals of the title compound with mp, 182°-186° with foaming. These crystals contained according to analytical data molar amounts of water.

Workup

  1. customThis compound was prepared
  2. customThe product was crystallized from ethanol

Sources & evidence

ORD record
ord-e7118b68d22444738543706958045fcf
Source dataset
uspto-grants-1990_09
Patent number
US04959361

Reaction notes

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