反应详情

温度

100 °C

To 2-bromoethanol (40.7 g, 326 mmol) was added conc. sulfuric acid (9.96 g, 102 mmol) under ice-cooling while stirring. Thereto was added benzhydrol (12.0 g, 65.1 mmol), and the mixture was heated at 100° C. for 15 minutes. The reaction mixture was allowed to stand for cooling, poured into ice-cold water and extracted with ether. The organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate and saturated brine, dried over anhydrous magnesium sulfate and evaporated. The thus-obtained liquid was distilled under reduced pressure to give the title compound (3). Yield 13.9 g (73%). b.p. 125°-165° C./2.5 mmHg.

1. temperaturecooling
2. temperaturefor cooling
3. additionpoured into ice-cold water
4. extractionextracted with ether
5. washThe organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate and saturated brine
6. dry with materialdried over anhydrous magnesium sulfate
7. customevaporated
8. distillationThe thus-obtained liquid was distilled under reduced pressure