反应详情

温度

50 °C

Sodium metal (100 mg, 4.3 mmol) was dissolved in methanol (5 mL) under a nitrogen atmosphere. A solution of 2-chloro-3-nitro-5-ethyl-6-methylpyridine (677 mg, 3.37 mmol) in methanol (5 mL) was added dropwise. The reaction was warmed at 50° C. for four hours. The reaction was cooled, diluted with diethyl ether, the ether layer washed with water, dried (Na2SO4), filtered through a pad of charcoal and evaporated to yield 535 mg (80%) of product.

1. temperatureThe reaction was cooled
2. washthe ether layer washed with water
3. dry with materialdried (Na2SO4)
4. filtrationfiltered through a pad of charcoal
5. customevaporated