HCID 10330159, compound → 2(1H)-Pyridinone, 5-butyl-6-methyl-

HRID 1033025Notes

Reaction equation

HRID 1033025 reaction equation
C([C:3]1[C:4](=[O:14])[NH:5][C:6]([CH3:13])=[C:7]([CH2:9][CH2:10][CH2:11][CH3:12])[CH:8]=1)#N>Cl>[CH2:9]([C:7]1[CH:8]=[CH:3][C:4](=[O:14])[NH:5][C:6]=1[CH3:13])[CH2:10][CH2:11][CH3:12]

Participants

3

Reactant 1

HCID 10330159HCID 10330159, compound

Product 1

HCID 104646792(1H)-Pyridinone, 5-butyl-6-methyl-Yield 68.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A suspension of 3-cyano-5-butyl-6-methylpyridin-2(1H)-one (950 mg, 5.0 mmol) in 6N hydrochloric acid (36 mL) was refluxed for 3 days. The reaction was cooled and extracted with methylene chloride to isolate product. It was then dried with methylene chloride solution, filtered and evaporated. The residue was triturated with diethyl ether to yield product (563 mg, 68%).

Workup

  1. temperaturewas refluxed for 3 days
  2. temperatureThe reaction was cooled
  3. extractionextracted with methylene chloride
  4. customto isolate product
  5. dry with materialIt was then dried with methylene chloride solution
  6. filtrationfiltered
  7. customevaporated
  8. customThe residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-91230b0ea95647a585348e4e086e5ce3
Source dataset
uspto-grants-1994_05
Patent number
US05308854

Reaction notes

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