HCID 10353055, compound → HCID 10375036, compound

HRID 1033027Notes

Reaction equation

HRID 1033027 reaction equation
[N+:1]([C:4]1[C:5](=[O:15])[NH:6][C:7]([CH3:14])=[C:8]([CH2:10][CH2:11][CH2:12][CH3:13])[CH:9]=1)([O-])=O>CO.O1CCCC1.[Pd]>[NH2:1][C:4]1[C:5](=[O:15])[NH:6][C:7]([CH3:14])=[C:8]([CH2:10][CH2:11][CH2:12][CH3:13])[CH:9]=1

Participants

5

Reactant 1

HCID 10353055HCID 10353055, compound

Product 1

HCID 10375036HCID 10375036, compoundYield 89%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3-nitro-5-butyl-6-methylpyridin-2(1H)-one (293 mg, 1.40 mmol) in methanol (10 mL) and tetrahydrofuran (10 mL) containing 5% palladium/carbon (120 mg) was hydrogenated at atmosphere pressure for 10-20 hours. The catalyst was filtered off and the solvent evaporated. This residue was triturated with diethyl ether to give 224 mg (89%) of grayish product.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent evaporated
  3. customThis residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-c7d73c249b0346ab93f06c6c61f42750
Source dataset
uspto-grants-1994_05
Patent number
US05308854

Reaction notes

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