Hydrochloric Acid → HCID 178485075, compound

HRID 1033051Notes

Reaction equation

HRID 1033051 reaction equation
[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[O:11][C:12]([CH2:15][NH:16][C:17]([NH:21][CH3:22])=[N:18][C:19]#[N:20])=[CH:13][CH:14]=2)[N:9]=1)[NH2:3].[ClH:23].C[OH:25]>>[ClH:23].[ClH:23].[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[O:11][C:12]([CH2:15][NH:16][C:17]([NH:21][CH3:22])=[N:18][C:19](=[O:25])[NH2:20])=[CH:13][CH:14]=2)[N:9]=1)[NH2:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178485037HCID 178485037, compound

Product 1

HCID 178485075HCID 178485075, compound

Conditions

Temperature
50 °C

Procedure

A mixture of 2-(diaminomethyleneamino)-4-[5-(2-cyano-3-methylguanidino)methylfuran-2-yl]thiazole (2.28 g) and 4M-dioxanic hydrogen chloride (10 ml) in methanol (20 ml) was stirred at ambient temperature for 19 hours and further at 50° C. for 5 hours. The resulting precipitate was collected by filtration, washed with methanol, and recrystallized from a mixture of methanol and water to afford 2-(diaminomethyleneamino)-4-[5-(2-carbamoyl-3-methylguanidino)methylfuran-2-yl]thiazole dihydrochloride (1.65 g).

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with methanol
  3. customrecrystallized from a mixture of methanol and water

Sources & evidence

ORD record
ord-f5d20f5f019741d7a383e4a6e0992f30
Source dataset
uspto-grants-1994_05
Patent number
US05308857

Reaction notes

Loading…