Sodium Hydroxide → HCID 10357226, compound

HRID 1033052Notes

Reaction equation

HRID 1033052 reaction equation
[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[O:11][C:12]([CH2:15][NH:16][C:17]([NH:19]C(=O)C3C=CC=CC=3)=[S:18])=[CH:13][CH:14]=2)[N:9]=1)[NH2:3].[OH-].[Na+]>CO>[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[O:11][C:12]([CH2:15][NH:16][C:17]([NH2:19])=[S:18])=[CH:13][CH:14]=2)[N:9]=1)[NH2:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10363611HCID 10363611, compound

Product 1

HCID 10357226HCID 10357226, compoundYield 73.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A suspension of 2-(diaminomethyleneamino)-4-[5-{3-(benzoyl)thioureido}methylfuran-2-yl]thiazole (3.20 g) and sodium hydroxide (0.32 g) in methanol (30 ml) was stirred at 60° C. for one hour. The reaction mixture was cooled in an ice bath and the resulting precipitate was collected by filtration and washed with methanol to afford 2-(diaminomethyleneamino)-4-(5-thioureidomethylfuran-2-yl)thiazole (1.73 g).

Workup

  1. temperatureThe reaction mixture was cooled in an ice bath
  2. filtrationthe resulting precipitate was collected by filtration
  3. washwashed with methanol

Sources & evidence

ORD record
ord-ba87d4c5274049688b601b5efe5265f9
Source dataset
uspto-grants-1994_05
Patent number
US05308857

Reaction notes

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