Chloroacetone → HCID 10088260, compound

HRID 1033053Notes

Reaction equation

HRID 1033053 reaction equation
[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[O:11][C:12]([CH2:15][NH:16][C:17]([NH2:19])=[S:18])=[CH:13][CH:14]=2)[N:9]=1)[NH2:3].Cl[CH2:21][C:22](=O)[CH3:23]>C(O)C>[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[O:11][C:12]([CH2:15][NH:16][C:17]3[S:18][CH:21]=[C:22]([CH3:23])[N:19]=3)=[CH:13][CH:14]=2)[N:9]=1)[NH2:3]

Participants

4

Reactant 2

HCID 6571ChloroacetoneHCID 10357226HCID 10357226, compound

Product 1

HCID 10088260HCID 10088260, compoundYield 83.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 2-(diaminomethyleneamino)-4-(5-thioureidomethylfuran-2-yl)thiazole (0.70 g) and chloroacetone (0.22 g) in ethanol (15 ml) was refluxed for 4 hours with stirring. The solvent was evaporated in vacuo and the residue was recrystallized from a mixture of methanol and diisopropyl ether to afford 2-(diaminomethyleneamino)-4-[5-(4-methylthiazol-2-yl)aminomethylfuran-2-yl]thiazole (0.66 g).

Workup

  1. temperaturewas refluxed for 4 hours
  2. customThe solvent was evaporated in vacuo
  3. customthe residue was recrystallized from a mixture of methanol and diisopropyl ether

Sources & evidence

ORD record
ord-814beca9a260499384c0a3b768d976da
Source dataset
uspto-grants-1994_05
Patent number
US05308857

Reaction notes

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