反应详情

2-Furoyl chloride (0.48 g) was added slowly to a solution of 4-(5-aminomethylfuran-2-yl)-2-(diaminomethyleneamino)thiazole (0.80 g) in N,N-dimethylformamide (20 ml) with cooling on an ice bath and the mixture was stirred for an hour with cooling on an ice bath. The solvent was removed under reduced pressure and the residue was chromatographed on a silica gel column eluting with a mixture of chloroform and methanol (30:1, (V/V). Recrystallization from methanol afforded 2-(diaminomethyleneamino)-4-[5-(2-furoyl)aminomethylfuran-2-yl]thiazole (0.20 g).

1. temperaturewith cooling on an ice bath
2. temperaturewith cooling on an ice bath
3. customThe solvent was removed under reduced pressure
4. customthe residue was chromatographed on a silica gel column
5. washeluting with a mixture of chloroform and methanol (30:1, (V/V)
6. customRecrystallization from methanol