Hydrazine hydrate (1:1) → HCID 10378221, compound

HRID 1033059Notes

Reaction equation

HRID 1033059 reaction equation
[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[O:11][C:12]([C:15]([O:17]C)=O)=[CH:13][CH:14]=2)[N:9]=1)[NH2:3].O.[NH2:20][NH2:21]>C(O)C>[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[O:11][C:12]([C:15]([NH:20][NH2:21])=[O:17])=[CH:13][CH:14]=2)[N:9]=1)[NH2:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 11777662HCID 11777662, compound

Product 1

HCID 10378221HCID 10378221, compoundYield 97.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-(diaminomethyleneamino)-4-(5-methoxycarbonylfuran-2-yl)thiazole (5.00 g) and hydrazine hydrate (9.40 g) in ethanol (50 ml) was refluxed for 4 hours with stirring. The mixture was cooled and the resulting precipitate was collected by filtration to afford 2-(diaminomethyleneamino)-4-(5-hydrazinocarbonylfuran-2yl)thiazole (4.86 g).

Workup

  1. temperatureThe mixture was cooled
  2. filtrationthe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-e52935e4f8c44a83ab1849db127f8001
Source dataset
uspto-grants-1994_05
Patent number
US05308857

Reaction notes

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