Methanesulfonic Acid → HCID 19086287, compound

HRID 1033065Notes

Reaction equation

HRID 1033065 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[NH2:6][C:7](=[N:9][C:10]1[S:11][CH:12]=[C:13]([C:15]2[O:16][C:17]([CH2:20][NH:21][C:22]([NH2:24])=[O:23])=[CH:18][CH:19]=2)[N:14]=1)[NH2:8]>CO>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[NH2:6][C:7](=[N:9][C:10]1[S:11][CH:12]=[C:13]([C:15]2[O:16][C:17]([CH2:20][NH:21][C:22]([NH2:24])=[O:23])=[CH:18][CH:19]=2)[N:14]=1)[NH2:8]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 10446374HCID 10446374, compound

Product 1

HCID 19086287HCID 19086287, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methanesulfonic acid (0.93 ml) was added to a mixture of 2-(diaminomethyleneamino)-4-(5-ureidomethylfuran-2-yl)thiazole (4.0 g) in methanol (60 ml) and the mixture was stirred for an hour at ambient temperature. The isolated precipitate was collected by filtration and the precipitate was recrystallized from a solution of an aqueous ethanol to give 2-(diaminomethyleneamino)-4-(5-ureidomethylfuran-2-yl)thiazole methanesulfonate (2.77 g). mp: 185° to 186° C.

Workup

  1. filtrationThe isolated precipitate was collected by filtration
  2. customthe precipitate was recrystallized from a solution of an aqueous ethanol

Sources & evidence

ORD record
ord-3160ca2e33954ce7b5932ca6af13b103
Source dataset
uspto-grants-1994_05
Patent number
US05308857

Reaction notes

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