反应详情

A suspension of 4-(5-aminomethylfuran-2-yl)-2-(diaminomethyleneamino)thiazole (1.6 g), imino(methylthio)methylcarbamic acid methylester (1.2 g) and triethylamine (1.5 g) was stirred at room temperature for 26 hours and then refluxed for 2.5 hours. Imino(methylthio)methylcarbamic acid methylester (1.0 g) was added to the reaction mixture and the mixture was refluxed for 10 hours. The solvent was removed under reduced pressure. The residue was chromatographed on a silica gel column eluting with a mixture of chloroform and methanol (10:1, V/V). Recrystallization from a mixture of methanol and diisopropyl ether afforded 2-(diaminomethyleneamino)-4-[5-(2-methoxycarbonylguanidino)methylfuran-2-yl]thiazole (530 mg).

1. temperaturerefluxed for 2.5 hours
2. temperaturethe mixture was refluxed for 10 hours
3. customThe solvent was removed under reduced pressure
4. customThe residue was chromatographed on a silica gel column
5. washeluting with a mixture of chloroform and methanol (10:1, V/V)
6. customRecrystallization
7. additionfrom a mixture of methanol and diisopropyl ether