反应详情

To a solution of the alcohol from Step 1 (1.46 g, 5.8 mmoL) in CH2Cl2 (50 mL) was added CCl4 (5.7 mL, 58 mmoL, 10 eq.) followed by Ph3P (3 g, 11.7 mmoL, 2 eq.). The resulting mixture was refluxed for 2 hr. The solvent was evaporated and a purification by flash chromatography on silica gel (hexanes: EtOAc; 8:2) gave the title compound.

1. temperatureThe resulting mixture was refluxed for 2 hr
2. customThe solvent was evaporated
3. customa purification by flash chromatography on silica gel (hexanes: EtOAc; 8:2)