HCID 10098693, compound → HCID 10254585, compound

HRID 1033120Notes

Reaction equation

HRID 1033120 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:26][C:27]2[CH:39]=[CH:38][C:30]([C:31]([O:33]C(C)(C)C)=[O:32])=[CH:29][CH:28]=2)[C:7](/[CH:10]=[C:11]2\[N:12]([CH2:22][CH2:23][CH2:24][CH3:25])[C:13](=[O:21])[N:14]([CH2:17][CH2:18][CH2:19][CH3:20])[C:15]\2=[O:16])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]>C(Cl)Cl.FC(F)(F)C(O)=O>[CH2:1]([C:5]1[N:6]([CH2:26][C:27]2[CH:39]=[CH:38][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=2)[C:7](/[CH:10]=[C:11]2\[N:12]([CH2:22][CH2:23][CH2:24][CH3:25])[C:13](=[O:21])[N:14]([CH2:17][CH2:18][CH2:19][CH3:20])[C:15]\2=[O:16])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 10098693HCID 10098693, compound

Product 1

HCID 10254585HCID 10254585, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

1,1-dimethylethyl Z-4-[[2-butyl-5-[(1,3-dibutyl-2,5-dioxo-4-imidazolidinylidene)methyl]-1H-imidazol-1-yl]methyl]benzoate (0.88 g, 1.64 mmol) was disolved in methylene chloride (16 mL) and trifluoroacetic acid (16 mL). After stirring for 3 hours the reaction mixture was evaporated in vacuo. Dilute NaHCO3 was added to adjust the pH to 6 and extracted with ethyl acetate. This extract was dried over MgSO4 and then evaporated in vacuo and purified via chromatograph (eluant methanol in chloroform).

Workup

  1. customwas evaporated in vacuo
  2. additionDilute NaHCO3 was added
  3. extractionextracted with ethyl acetate
  4. dry with materialThis extract was dried over MgSO4
  5. customevaporated in vacuo
  6. custompurified via chromatograph (eluant methanol in chloroform)

Sources & evidence

ORD record
ord-9646b65e35e84621b3834f4c2a527675
Source dataset
uspto-grants-1994_05
Patent number
US05308853

Reaction notes

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