Dicyclohexylcarbodiimide → HCID 67823995, compound

HRID 1033133Notes

Reaction equation

HRID 1033133 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]2[C@H:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:14][O:13][C:12]2=[O:22])=[CH:6][CH:5]=1)([OH:3])=[O:2].[CH2:23]([O:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]2[CH:45]=[CH:44][C:43](O)=[CH:42][CH:41]=2)=[CH:36][CH:35]=1)[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32].C1CCC(N=C=NC2CCCCC2)CC1>CN(C1C=CN=CC=1)C.C(Cl)Cl>[CH2:23]([O:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]2[CH:45]=[CH:44][C:43]([O:2][C:1]([C:4]3[CH:5]=[CH:6][C:7]([CH2:10][N:11]4[C@H:15]([C:16]5[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=5)[CH2:14][O:13][C:12]4=[O:22])=[CH:8][CH:9]=3)=[O:3])=[CH:42][CH:41]=2)=[CH:36][CH:35]=1)[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]

Participants

6

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 10616140[1,1'-Biphenyl]-4-ol, 4'-(decyloxy)-HCID 54353650HCID 54353650, compound

Product 1

HCID 67823995HCID 67823995, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

505 mg (1.07 mmol) of (4R)-(-)-3-(4-carboxyphenylmethyl)-4-phenyl-2-oxazolidinone and 555 mg (1.7 mmol) of 4-decyloxy-4'-hydroxybiphenyl and 31 mg of DMAP are dissolved in 17 ml of absolute CH2Cl2, and 390 mg (1.7 mmol) of DCCI are added. The crude product is purified by chromatography.

Workup

  1. customThe crude product is purified by chromatography

Sources & evidence

ORD record
ord-2ae51e39cb7843bb89fda1b903326ac1
Source dataset
uspto-grants-1994_05
Patent number
US05310499

Reaction notes

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