反应详情

2-benzyloxynaphthalene-6-carboxylic acid chloride (6.4 g) was dissolved in 50 ml of methylene chloride and added in small portions to a solution of 1-octanol (2.6 g), dimethylaminopyridine (0.7 g) and triethylamine (2.1 g) in 30 ml of methylene chloride under ice-cooling. After the reaction mixture was stirred for about 20 hours, it was poured into ice-water and extracted with methylene chloride. The solvent was removed by evaporation to give a crude product, which was then subjected to silica gel column chromatography (eluent: hexane/ethylacetate=10/0.5) to give 2.6 g of 2-benzyloxy-6-octyloxycarbonylnaphthalene.

1. temperaturecooling
2. extractionextracted with methylene chloride
3. customThe solvent was removed by evaporation
4. customto give a crude product, which