Methylhydrazine → HCID 19025443, compound

HRID 1033191Notes

Reaction equation

HRID 1033191 reaction equation
[CH2:1]([N:3]([CH2:15][CH3:16])[C:4]1[C:9]([F:10])=[CH:8][C:7]([N:11]=[C:12]=[S:13])=[C:6]([F:14])[CH:5]=1)[CH3:2].[CH3:17][NH:18][NH2:19]>C(O)C>[CH2:15]([N:3]([CH2:1][CH3:2])[C:4]1[C:9]([F:10])=[CH:8][C:7]([NH:11][C:12](=[S:13])[N:18]([CH3:17])[NH2:19])=[C:6]([F:14])[CH:5]=1)[CH3:16]

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 19025453HCID 19025453, compound

Product 1

HCID 19025443HCID 19025443, compoundYield 98.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following procedures similar to those employed in Step A of Example 2, the reaction of 2.9 g (0.012 mole) of 4-diethylamino-2,5-difluorophenyl isothiocyanate with 0.55 g (0.012 mole) of methylhydrazine in 75 ml of ethanol yielded 3.4 g of 4-(4-diethylamino-2,5-difluorophenyl) -2-methyl-3-thiosemicarbazide. The nmr spectrum was consistent with the proposed structure.

Sources & evidence

ORD record
ord-aefd716ee15348ffae301746c4e9bdd0
Source dataset
uspto-grants-1994_05
Patent number
US05310724

Reaction notes

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