HCID 86747828, compound → (cis) 3,3,5-Trimethylcyclohexyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropionate

HRID 1033231Notes

Reaction equation

HRID 1033231 reaction equation
[Cl:1][C:2]1[CH:34]=[CH:33][C:5]([C:6]([NH:8][CH2:9][CH2:10][C:11]2[CH:32]=[CH:31][C:14]([O:15][C:16]([CH3:30])([CH3:29])[C:17]([O:19][C@H:20]3[CH2:25][C@H:24]([CH3:26])[CH2:23][C:22]([CH3:28])([CH3:27])[CH2:21]3)=[O:18])=[CH:13][CH:12]=2)=[O:7])=[CH:4][CH:3]=1>[K+].[Br-]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH2:9][CH2:10][C:11]2[CH:32]=[CH:31][C:14]([O:15][C:16]([CH3:29])([CH3:30])[C:17]([O:19][C@H:20]3[CH2:25][C@@H:24]([CH3:26])[CH2:23][C:22]([CH3:27])([CH3:28])[CH2:21]3)=[O:18])=[CH:13][CH:12]=2)=[O:7])=[CH:33][CH:34]=1

Participants

3

Reactant 1

HCID 86747828HCID 86747828, compound

Product 1

HCID 86747829(cis) 3,3,5-Trimethylcyclohexyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropionate

Reagents, catalysts & solvents 1

HCID 253877Potassium BromideSolvent

Procedure

The reaction is carried out under the same conditions as in Example 3 and with the same proportions of reactants. After chromatography on a silica column, the product can be recrystallized from ethyl acetate to give the title derivative in the form of white crystals melting at 122° C. (capillary). Thin layer chromatography under the conditions already described shows a single spot whose Rf of 0.2 is identical to that of the product of Example 3. The IR spectrum run in KBr has the same principal characteristic bands as in Example 3, although the fine bands between 1000 and 600 cm-1 are markedly different.

Sources & evidence

ORD record
ord-ddeb70bed69946b6aa1b9548c4483e62
Source dataset
uspto-grants-1994_05
Patent number
US05310757

Reaction notes

Loading…