反应详情

(Compound 14) (10.1 g) was dissolved in acetone (200 ml) saturated with NaI. The mixture was refluxed for 12 h and subsequently stirred at RT for 3 days. The mixture was evaporated to dryness and the residue extracted with H2O/ether. The etheral layer separated and washed with H2O and saturated NaCl-solution. Resulting in 12.5 g of 3-iodo-1-phenyl-1-propanol (compound 15).

1. temperatureThe mixture was refluxed for 12 h
2. customThe mixture was evaporated to dryness
3. extractionthe residue extracted with H2O/ether
4. customThe etheral layer separated
5. washwashed with H2O and saturated NaCl-solution