6-((tert-Butoxycarbonyl)amino)hexanoic acid → HCID 19025520, compound

HRID 1033379Notes

Reaction equation

HRID 1033379 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:17][CH:18]1[CH2:24][CH2:23][C:22]2[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=2[NH:20][C:19]1=[O:29]>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([NH:17][CH:18]1[CH2:24][CH2:23][C:22]2[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=2[NH:20][C:19]1=[O:29])=[O:16])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 6376026-((tert-Butoxycarbonyl)amino)hexanoic acidHCID 44344333-Amino-2,3,4,5-tetrahydro-1H-benzazepin-2-one

Product 1

HCID 19025520HCID 19025520, compound

Procedure

Prepared from 6-(t-butoxycarbonylamino)hexanoic acid and 3-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (Example 1, Step A) by the procedure described in Example 25, Step A. 1H NMR (200 MHz, CDCl3): 1.2-1.7 (m,14 H), 1.92 (m,2 H), 2.16 (t,5 Hz,1 H), 2.5-3.1 (m,6 H), 4.53 (m,2 H), 6.54 (d,7 Hz,1 H), 6.96 (m,1 H), 7.18 (m,3 H), 8.00 (s,1 H). FAB-MS: calculated for C21H31N3O4 389; found 390 (M+H,18%).

Sources & evidence

ORD record
ord-7dd8a6e9cc8248fa8d8eaa3598004c30
Source dataset
uspto-grants-1994_05
Patent number
US05310737

Reaction notes

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