Hydrogen Peroxide → Tert-butyl 4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate

HRID 103338Notes

Reaction equation

HRID 103338 reaction equation
[BH4-:21].[CH3:27][O:28][CH2:29][CH2:30][O:31][CH3:32].[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]2=[CH:13][CH2:12][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:10][CH2:9]2)[cH:6][cH:7]1.[K+:24].[Na+:22].[OH-:23].[OH2:33].[OH:25][OH:26]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH:13]2[OH:23])[cH:6][cH:7]1

Participants

9

Reactant 8

HCID 784Hydrogen PeroxideHCID 813Potassium CationHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 80711,2-DimethoxyethaneHCID 28123BorohydrideHCID 157514261,1-Dimethylethyl 4-(4-fluorophenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Product 1

HCID 45074236Tert-butyl 4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-1dcd557414d34092bae763014df6b94a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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