3-Amino-2,3,4,5-tetrahydro-1H-benzazepin-2-one → 2(S),6-Di-(t-butoxycarbonylamino)-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-hexanamide

Participants

Reaction Steps

Prepared from Na, Ne -di(t-butoxycarbonyl)L-lysine and 3-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (Example 1, Step A) by the procedure described in Example 25, Step A. 1H NMR (200 MHz, CDCl3): 1.2-2.1 (m,24 H), 2.6-3.3 (m,6 H), 4.20 (m,1 H), 4.62 (m,2H), 5.26 (m,1H), 7.0-7.4 (m,4 H). FAB-MS: calculated for C26H40N4O6 504; found 505 (M+H,20%).

Provenance & Evidence