3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid → HCID 19025547, compound

HRID 1033404Notes

Reaction equation

HRID 1033404 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]([CH3:15])([CH3:14])[CH2:10][C:11]([OH:13])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:16][CH:17]1[CH2:23][CH2:22][C:21]2[CH:24]=[C:25]([O:28][CH3:29])[CH:26]=[CH:27][C:20]=2[NH:19][C:18]1=[O:30]>>[C:1]([O:5][C:6]([NH:8][C:9]([CH3:15])([CH3:14])[CH2:10][C:11]([NH:16][CH:17]1[CH2:23][CH2:22][C:21]2[CH:24]=[C:25]([O:28][CH3:29])[CH:26]=[CH:27][C:20]=2[NH:19][C:18]1=[O:30])=[O:13])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 103760463-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acidHCID 19076185HCID 19076185, compound

Product 1

HCID 19025547HCID 19025547, compound

Procedure

Prepared from 3-t-butoxycarbonylamino-3-methylbutanoic acid (Example 31, Step E) and the amine obtained in Step D by the procedure described in Example 1, Step F. 1H NMR (200 MHz, CDCl3): 1.32 (s,6H), 1.38 (s,9H), 1.86 (m,1H), 2.4-3.0 (m,5H), 3.77 (s,3H), 4.49 (m,1H), 5.25 9br s,1H), 6.68 (d,8 Hz, 1H), 6.70 (s,1H), 6.89 (d,8 Hz, 1H), 7.55 (br s,1H). FAB-MS: calculated for C21H31N3O5 405; found 428 (m+na,100%), 406 M+H,23%).

Sources & evidence

ORD record
ord-95b001c847064a6f8893ac9b1d5e0af6
Source dataset
uspto-grants-1994_05
Patent number
US05310737

Reaction notes

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