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N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanine → 2-t-Butoxycarbonylamino-2-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]propanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanine | HCID 2733845 | — |
| 反応物 | (R)-3-amino-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one | HCID 10103689 | — |
| 生成物 | 2-t-Butoxycarbonylamino-2-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]propanamide | HCID 10808566 | — |
反応手順
Prepared from 2-(t-butoxycarbonylamino)-2-methylpropanoic acid and 3(R)-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (Example 1, Step B) by the procedure described in Example 1, Step F. 1H NMR (200MHz, CDCl3): 1.42 (s,12H), 1.46 (s,3H), 1.90 (m,1H), 2.5-3.0 (m,3H), 4.48 (m,1H), 5.01 (br s,1H), 6.97 (d,8Hz,1H), 7.1-7.3 (m,3H), 7.9 (br s,1H). FAB=MS: calculated for C19H27N3O4 361; found 362 (M+H,30%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05310737 |
| 出典データセット | uspto-grants-1994_05 |
| ORD ID | ord-4b250e9289a34e9eb3fd3f51df9795e1 |
| 出典メモ | uspto-grants-1994_05 |