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HRID 1033409作成日：2026年10月25日

(R)-3-amino-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one → 3-(Benzyloxycarbonylamino)-2,2-dimethyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-propanamide

https://huagongshe.com/reaction/1033409

反応式

関与物質

役割名称HCID仕込み量
反応物(R)-3-amino-4,5-dihydro-1H-benzo[b]azepin-2(3H)-oneHCID 10103689—
反応物3-(((Benzyloxy)carbonyl)amino)-2,2-dimethylpropanoic acidHCID 14551010—
生成物3-(Benzyloxycarbonylamino)-2,2-dimethyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-propanamideHCID 18651458—

反応手順

Prepared from 3-(benzyloxycarbonylamino)-2,2-dimethylpropanoic acid and 3(R)-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (Example 1, Step E) by the procedure described in Example 1, Step F. 1H NMR (200MHz, CDCl3): 1.19 (s,6H), 1.90 (m,1H), 2.6-3.0 (n,3H), 3.26 (d,6Hz,2H), 4.46 (m,1H), 5.07 (s,2H), 5.7 (br t,1H), 6.62 (d,7Hz,1H), 6.97 (d,8Hz,1H), 7.1-7.3 (m,3H), 7.3 (s,5H), 8.14 (br s,1H). FAB-MS: calculated for C23H27N3O4 409; found 410 (M+H,100%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05310737
出典データセットuspto-grants-1994_05
ORD IDord-6d762eae435b4c29b20d2cec336827a7
出典メモuspto-grants-1994_05