2'-Bromoacetophenone → 1-(4'-Methyl[1,1'-biphenyl]-2-yl)ethanone

HRID 1033423Notes

Reaction equation

HRID 1033423 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([Sn](C)(C)C)=[CH:4][CH:3]=1.Br[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19](=[O:21])[CH3:20]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19](=[O:21])[CH3:20])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 750602'-BromoacetophenoneHCID 617834Stannane, trimethyl(4-methylphenyl)-

Product 1

HCID 98372111-(4'-Methyl[1,1'-biphenyl]-2-yl)ethanone

Procedure

Prepared from 4-methylphenyltrimethylstannane (Example 69, Step A) and 2'-bromoacetophenone by the procedure described in Example 69, Step B. 1H NMR (200 MHz,CDCl3): 1.98 (s,3H), 2.37 (s,3H), 7.20 (s,4H), 7.3-7.5 (m,4H). FAB-MS: calculated for C15H14O 210; found 211 (M+H,100%).

Sources & evidence

ORD record
ord-0ef530f687484adb8ed2531dda6f22bf
Source dataset
uspto-grants-1994_05
Patent number
US05310737

Reaction notes

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