Formaldehyde → HCID 15701915, compound

HRID 1033489Notes

Reaction equation

HRID 1033489 reaction equation
[C:1]1([C@H:7]([NH:9][CH2:10][Si:11]([CH3:14])([CH3:13])[CH3:12])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:15]=[O:16]>C(O)CCC>[C:1]1([C@H:7]([N:9]([CH2:10][Si:11]([CH3:13])([CH3:12])[CH3:14])[CH2:15][O:16][CH2:6][CH2:1][CH2:2][CH3:3])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 13526350HCID 13526350, compound

Product 1

HCID 15701915HCID 15701915, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

The title compound was prepared from (R)-(+)-N-1-phenylethyl-N-trimethylsilylmethylamine by reaction with n-butanol and aqueous formaldehyde following the procedure of Example 2 to give the crude acetal (85% pure) as a colourless oil (34.2 g, 84%). The nmr spectrum was identical to the above (S)-isomer.

Sources & evidence

ORD record
ord-a3a0256718b84ea8b34df7e1b9fb8eb2
Source dataset
uspto-grants-1994_05
Patent number
US05310911

Reaction notes

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