反应详情

温度

60 °C

A mixture comprising 6.0 g of 1-(1-propenyl)-2nitroiminoimidazolidine, 7.0 g of potassium carbonate, 70 ml of DMSO and 7.4 g of 2-chloro-5-chloromethylpyridine was stirred at 60° C. for one hour. The reaction mixture was poured into water, extracted with ethyl acetate, washed with water, dried (with anhydrous MgSO4) and concentrated to give an oily residue. This was purified by column chromatography (silica gel, eluent: ethyl acetate/hexane=2/1) to give 8.6 g of 1-(2-chloropyridin-5-ylmethyl)-2-nitroimino -3- (1propenyl)imidazolidine.

1. extractionextracted with ethyl acetate
2. washwashed with water
3. dry with materialdried (with anhydrous MgSO4)
4. concentrationconcentrated
5. customto give an oily residue
6. customThis was purified by column chromatography (silica gel, eluent: ethyl acetate/hexane=2/1)