Lithium Hydroxide → HCID 15341824, compound

HRID 1033644Notes

Reaction equation

HRID 1033644 reaction equation
[CH3:1][O:2][C:3]1[C:4]([CH2:34][CH2:35][CH3:36])=[C:5]([CH:27]=[CH:28][C:29]=1[C:30]([NH:32][CH3:33])=[O:31])[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[C:12]([CH2:24][CH2:25][CH3:26])=[C:13]([CH:21]=[CH:22][CH:23]=1)[O:14][CH2:15][C:16]([O:18]CC)=[O:17].[OH-].[Li+]>CO>[CH3:1][O:2][C:3]1[C:4]([CH2:34][CH2:35][CH3:36])=[C:5]([CH:27]=[CH:28][C:29]=1[C:30]([NH:32][CH3:33])=[O:31])[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[C:12]([CH2:24][CH2:25][CH3:26])=[C:13]([CH:21]=[CH:22][CH:23]=1)[O:14][CH2:15][C:16]([OH:18])=[O:17]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 15341823HCID 15341823, compound

Product 1

HCID 15341824HCID 15341824, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound of Example 45 (70 mg, 0.1395 mmol) and 279 μl of 1M lithium hydroxide was added to 2.0 ml of methanol, and the reaction mixture was stirred at room temperature overnight. The solvent was removed under vacuum and 2.0 ml of water was added, and the solution was acidified with 10% hydrochloric acid and then extracted three times with ethyl acetate. The extracts were combined and the solvent was removed under vacuum to give the product.

Workup

  1. customThe solvent was removed under vacuum and 2.0 ml of water
  2. additionwas added
  3. extractionextracted three times with ethyl acetate
  4. customthe solvent was removed under vacuum
  5. customto give the product

Sources & evidence

ORD record
ord-a7ea914a25cb4f9f8d7fc98471358b5a
Source dataset
uspto-grants-1994_05
Patent number
US05310951

Reaction notes

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