Trifluoroacetic acid → HCID 86747843, compound

Participants

Reaction Steps

9.4 ml of trifluoroacetic acid and 0.31 ml of trifluoromethanesulfonic acid were added, whilst ice-cooling, to a solution of 940 mg of (2S,4S)-2-(3,4-dimethyl-1-piperazinylcarbonyl)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)pyrrolidine (prepared as described in Preparation 13) in 1.88 ml of anisole, and the resulting mixture was stirred at room temperature for 1 hour. At the end of this time, the reaction mixture was treated in a similar manner to that described in Example 13(1), to give 1.2 g of the title compound as a powder.

Provenance & Evidence