Trifluoroacetic acid → HCID 86747843, compound

HRID 1033680Notes

Reaction equation

HRID 1033680 reaction equation
FC(F)(F)C(O)=O.[F:8][C:9]([F:15])([F:14])[S:10]([OH:13])(=[O:12])=[O:11].[CH3:16][CH:17]1[N:22]([CH3:23])[CH2:21][CH2:20][N:19]([C:24]([C@@H:26]2[CH2:30][C@H:29]([S:31]CC3C=CC(OC)=CC=3)[CH2:28][N:27]2[C:41]([O:43][CH2:44][C:45]2[CH:50]=[CH:49][C:48]([N+:51]([O-:53])=[O:52])=[CH:47][CH:46]=2)=[O:42])=[O:25])[CH2:18]1>C1(OC)C=CC=CC=1>[F:8][C:9]([F:15])([F:14])[S:10]([OH:13])(=[O:12])=[O:11].[F:8][C:9]([F:15])([F:14])[S:10]([OH:13])(=[O:12])=[O:11].[CH3:16][CH:17]1[N:22]([CH3:23])[CH2:21][CH2:20][N:19]([C:24]([C@@H:26]2[CH2:30][C@H:29]([SH:31])[CH2:28][N:27]2[C:41]([O:43][CH2:44][C:45]2[CH:46]=[CH:47][C:48]([N+:51]([O-:53])=[O:52])=[CH:49][CH:50]=2)=[O:42])=[O:25])[CH2:18]1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 62406Trifluoromethanesulfonic acidHCID 57280473HCID 57280473, compound

Product 1

HCID 86747843HCID 86747843, compound

Reagents, catalysts & solvents 1

HCID 7519AnisoleSolvent

Procedure

9.4 ml of trifluoroacetic acid and 0.31 ml of trifluoromethanesulfonic acid were added, whilst ice-cooling, to a solution of 940 mg of (2S,4S)-2-(3,4-dimethyl-1-piperazinylcarbonyl)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)pyrrolidine (prepared as described in Preparation 13) in 1.88 ml of anisole, and the resulting mixture was stirred at room temperature for 1 hour. At the end of this time, the reaction mixture was treated in a similar manner to that described in Example 13(1), to give 1.2 g of the title compound as a powder.

Workup

  1. additionAt the end of this time, the reaction mixture was treated in a similar manner to that

Sources & evidence

ORD record
ord-256c0c4f032748399f1026b55b13ea32
Source dataset
uspto-grants-1994_05
Patent number
US05310735

Reaction notes

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