1,4-Dioxane → HCID 131718405, compound

HRID 1033712Notes

Reaction equation

HRID 1033712 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:12](=[O:13])[C:11]2[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=2[S:9][CH2:8][C:7]1=[O:18].[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1N1CCNCC1.O1[CH2:36][CH2:35]OCC1>>[N:21]1[CH:22]=[CH:23][CH:24]=[N:19][C:20]=1[CH:36]1[CH2:35][CH2:7][N:6]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[C:12](=[O:13])[C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[S:9][CH2:8][C:7]2=[O:18])[CH2:5][CH2:4]1

Participants

4

Reactant 3

HCID 312751,4-DioxaneHCID 887471-(2-Pyrimidinyl)piperazineHCID 15233924HCID 15233924, compound

Product 1

HCID 131718405HCID 131718405, compoundYield 52%

Procedure

To a solution of 53.8 of the compound of Example 13 dissolved in 10 ml of dioxane was added 84.3 mg (3 equivalents) of 1-(2-pyrimidinyl)piperazine, and the mixture heated under reflux for 6 hours. The reaction treatment and purification were conducted in the same manner as in Example 17 to obtain 35.2 mg of the desired compound (yield 52%). The maleate was obtained by converting the product to maleate in a conventional manner, followed by recrystallization from methylene chloride-ether.

Workup

  1. temperaturethe mixture heated
  2. temperatureunder reflux for 6 hours
  3. customThe reaction treatment and purification

Sources & evidence

ORD record
ord-6c366c7504c947abad1b2b95feee52f2
Source dataset
uspto-grants-1994_05
Patent number
US05312625

Reaction notes

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