1,4-Dioxane → HCID 131718405, compound

Participants

Reaction Steps

To a solution of 53.8 of the compound of Example 13 dissolved in 10 ml of dioxane was added 84.3 mg (3 equivalents) of 1-(2-pyrimidinyl)piperazine, and the mixture heated under reflux for 6 hours. The reaction treatment and purification were conducted in the same manner as in Example 17 to obtain 35.2 mg of the desired compound (yield 52%). The maleate was obtained by converting the product to maleate in a conventional manner, followed by recrystallization from methylene chloride-ether.

Provenance & Evidence