1-Phenylpiperazine → HCID 15233926, compound

Participants

Reaction Steps

To a solution of 69.4 mg of the compound of Example 16 dissolved in 10 ml of dioxane was added 109 mg (3 equivalents) of N-phenylpiperazine, and the mixture heated under reflux for 17 hours. The reaction treatment and purification were conducted in the same manner as in Example 17 to obtain 63.5 mg of the desired compound (yield 72.5%). The fumarate was obtained by converting the product to fumarate in a conventional manner, followed by recrystallization from acetoneether.

Provenance & Evidence