1-Phenylpiperazine → HCID 15233926, compound

HRID 1033715Notes

Reaction equation

HRID 1033715 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:12](=[O:13])[CH2:11][CH2:10][C:9]2[CH:14]=[CH:15][CH:16]=[CH:17][C:8]=2[C:7]1=[O:18].[C:19]1([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>O1CCOCC1>[C:19]1([N:25]2[CH2:30][CH2:29][N:28]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]3[C:12](=[O:13])[CH2:11][CH2:10][C:9]4[CH:14]=[CH:15][CH:16]=[CH:17][C:8]=4[C:7]3=[O:18])[CH2:27][CH2:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 70961-PhenylpiperazineHCID 19024280HCID 19024280, compound

Product 1

HCID 15233926HCID 15233926, compoundYield 72.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 69.4 mg of the compound of Example 16 dissolved in 10 ml of dioxane was added 109 mg (3 equivalents) of N-phenylpiperazine, and the mixture heated under reflux for 17 hours. The reaction treatment and purification were conducted in the same manner as in Example 17 to obtain 63.5 mg of the desired compound (yield 72.5%). The fumarate was obtained by converting the product to fumarate in a conventional manner, followed by recrystallization from acetoneether.

Workup

  1. temperaturethe mixture heated
  2. temperatureunder reflux for 17 hours
  3. customThe reaction treatment and purification

Sources & evidence

ORD record
ord-39545351c7df427abd1ad5805973b23e
Source dataset
uspto-grants-1994_05
Patent number
US05312625

Reaction notes

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