1-(2-Pyridyl)piperazine → HCID 19024286, compound

Participants

Reaction Steps

To a solution of 101 mg of the compound of Example 16 dissolved in 10 ml of dioxane was added 0.152 ml (3 equivalents) of 1-(2-pyridyl)piperazine, followed by heating under reflux for 8 hours. The reaction treatment and purification were conducted in the same manner as in Example 17 to obtain 116 mg of the desired compound (yield 91%). The maleate was obtained by converting the product to maleate in a conventional manner, followed by recrystallization from methylene chloride-ether.

Provenance & Evidence