1-(2-Pyridyl)piperazine → HCID 19024286, compound

HRID 1033716Notes

Reaction equation

HRID 1033716 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:12](=[O:13])[CH2:11][CH2:10][C:9]2[CH:14]=[CH:15][CH:16]=[CH:17][C:8]=2[C:7]1=[O:18].[N:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>O1CCOCC1>[N:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N:25]1[CH2:26][CH2:27][N:28]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[C:12](=[O:13])[CH2:11][CH2:10][C:9]3[CH:14]=[CH:15][CH:16]=[CH:17][C:8]=3[C:7]2=[O:18])[CH2:29][CH2:30]1

Participants

4

Reactant 2

HCID 944591-(2-Pyridyl)piperazineHCID 19024280HCID 19024280, compound

Product 1

HCID 19024286HCID 19024286, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 101 mg of the compound of Example 16 dissolved in 10 ml of dioxane was added 0.152 ml (3 equivalents) of 1-(2-pyridyl)piperazine, followed by heating under reflux for 8 hours. The reaction treatment and purification were conducted in the same manner as in Example 17 to obtain 116 mg of the desired compound (yield 91%). The maleate was obtained by converting the product to maleate in a conventional manner, followed by recrystallization from methylene chloride-ether.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 8 hours
  3. customThe reaction treatment and purification

Sources & evidence

ORD record
ord-3af5e24e87ba4e79aa5ea21689047d38
Source dataset
uspto-grants-1994_05
Patent number
US05312625

Reaction notes

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