1-(2-Pyrimidinyl)piperazine → HCID 19024282, compound

HRID 1033717Notes

Reaction equation

HRID 1033717 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:12](=[O:13])[CH2:11][CH2:10][C:9]2[CH:14]=[CH:15][CH:16]=[CH:17][C:8]=2[C:7]1=[O:18].[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>O1CCOCC1>[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1[N:25]1[CH2:30][CH2:29][N:28]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[C:12](=[O:13])[CH2:11][CH2:10][C:9]3[CH:14]=[CH:15][CH:16]=[CH:17][C:8]=3[C:7]2=[O:18])[CH2:27][CH2:26]1

Participants

4

Reactant 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 19024280HCID 19024280, compound

Product 1

HCID 19024282HCID 19024282, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 99.3 mg of the compound of Example 16 dissolved in 10 ml of dioxane was added 158 mg (3 equivalents) of 1-(2-pyrimidinyl)piperazine, followed by heating under reflux for 8 hours. The reaction treatment and purification were conducted similarly as in Example 17 to obtain 109 mg of the desired compound (yield 87%). The maleate was obtained by converting the product to maleate in a conventional manner, followed by recrystallization from methylene chloride-ether.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 8 hours
  3. customThe reaction treatment and purification

Sources & evidence

ORD record
ord-9d2a9c0425f24b2fb3481e7e4f978dbe
Source dataset
uspto-grants-1994_05
Patent number
US05312625

Reaction notes

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