1-(2-Pyrimidinyl)piperazine → HCID 19024282, compound

Participants

Reaction Steps

To a solution of 99.3 mg of the compound of Example 16 dissolved in 10 ml of dioxane was added 158 mg (3 equivalents) of 1-(2-pyrimidinyl)piperazine, followed by heating under reflux for 8 hours. The reaction treatment and purification were conducted similarly as in Example 17 to obtain 109 mg of the desired compound (yield 87%). The maleate was obtained by converting the product to maleate in a conventional manner, followed by recrystallization from methylene chloride-ether.

Provenance & Evidence