2-(N-Ethoxycarbonyl-N-propargylaminomethyl)-pyrimidine → ethyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

HRID 1033745Notes

Reaction equation

HRID 1033745 reaction equation
[CH2:1]([O:3][C:4]([N:6]([CH2:10][C:11]1[N:16]=[CH:15][CH:14]=[CH:13]N=1)[CH2:7][C:8]#C)=[O:5])[CH3:2]>C1(C)C(C)=CC=CC=1>[N:16]1[CH:15]=[CH:14][CH:13]=[C:8]2[CH2:7][N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:10][C:11]=12

Participants

3

Reactant 1

HCID 189536422-(N-Ethoxycarbonyl-N-propargylaminomethyl)-pyrimidine

Product 1

HCID 18953634ethyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

7.7 g (35 mmol) of 2-(N-ethoxycarbonyl-N-propargylaminomethyl)-pyrimidine are refluxed for 40 hours in 150 ml of xylene. The mixture is concentrated, and the residue is recrystallised from ligroin.

Workup

  1. concentrationThe mixture is concentrated
  2. customthe residue is recrystallised from ligroin

Sources & evidence

ORD record
ord-9befbd0e928f41b4a752bf004b0bbba9
Source dataset
uspto-grants-1994_05
Patent number
US05312823

Reaction notes

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