Hydrochloric Acid → 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine--hydrogen chloride (1/2)

HRID 1033747Notes

Reaction equation

HRID 1033747 reaction equation
[CH2:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH2:3][N:2]1C(OCC)=O.[ClH:15]>>[ClH:15].[ClH:15].[CH2:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH2:3][NH:2]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18953633ethyl 1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate

Product 1

HCID 189536442,3-Dihydro-1H-pyrrolo[3,4-c]pyridine--hydrogen chloride (1/2)

Procedure

10.4 g (51 mmol) of ethyl 2,3-dihydro-1H-pyrrolo-[3,4-c]pyridine-2-carboxylate are refluxed for 15 hours together with 100 ml of concentrated hydrochloric acid. The batch is evaporated, and the crystalline residue is stirred with acetone. The product is filtered off with suction and dried in the air.

Workup

  1. customThe batch is evaporated
  2. filtrationThe product is filtered off with suction
  3. customdried in the air

Sources & evidence

ORD record
ord-da275ca293f44d51a9ea56983ed6266b
Source dataset
uspto-grants-1994_05
Patent number
US05312823

Reaction notes

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