HCID 19024460, compound → HCID 19024424, compound

HRID 1033813Notes

Reaction equation

HRID 1033813 reaction equation
[CH2:1]([N:5]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[S:33](=[O:40])(=[O:39])[NH:34]C(C)(C)C)=[CH:23][CH:22]=1)[C:6]([N:8]([CH3:19])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]([F:18])([F:17])[F:16])=[O:7])[CH2:2][CH2:3][CH3:4]>CCCCCC.CCOC(C)=O>[CH2:1]([N:5]([CH2:20][C:21]1[CH:22]=[CH:23][C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[S:33](=[O:39])(=[O:40])[NH2:34])=[CH:25][CH:26]=1)[C:6]([N:8]([CH3:19])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]([F:18])([F:16])[F:17])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 19024460HCID 19024460, compound

Product 1

HCID 19024424HCID 19024424, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound was prepared from 1-butyl-1-[[2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl]-3-methyl-3-[2-(trifluoromethyl)phenyl]urea (from Step B) according to the procedure of Example 2, Step D. Purification of the crude product by flash chromatography (elution with 2:1 and then 1:1 hexane-EtOAc) afforded a 76% yield of a stiff, white foam, which became tacky upon standing; homogeneous by TLC (3:1 hexane-EtOAc); FAB-MS m/e 521 (M+1)+.

Workup

  1. customPurification of the crude product by flash chromatography (
  2. washelution with 2:1
  3. custom1:1 hexane-EtOAc) afforded a 76% yield of a stiff, white foam, which

Sources & evidence

ORD record
ord-dc2d509e6d1f49deb5c901ee3040c163
Source dataset
uspto-grants-1994_05
Patent number
US05312820

Reaction notes

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