HRID1033820

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

HCID887

Methanol

CH4O

结构：CCCCCN(Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1)C(=O)N(C)c1ccccc1C(F)(F)F

HCID19024452

未命名化合物

PRODUCTS

生成物

结构：CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)C(=O)N(C)c1ccccc1C(F)(F)F

HCID178446315

未命名化合物

收率 31%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

By the procedure of Example 8, Step D, 1-methyl-3-pentyl-1-[2-(trifluoromethyl)phenyl]-3-[[2'(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]urea (from Step A) was deprotected with aqueous acetic acid. The residual oil was flash chromatographed on silica gel (elution with 3% and then 5% MeOH in CH2Cl2) to give a 31% yield of the title compound as a stiff foam, homogeneous by TLC (95:5 CH2Cl2 -MeOH); FAB-MS m/e 523 (M+1).

WORKUP

后处理

customchromatographed on silica gel (
washelution with 3%

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6bde664c63b041b5ae1cb9666cb09e90
来源数据集: uspto-grants-1994_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05312820
来源说明: uspto-grants-1994_05

反应 SMILES

[CH3:1][N:2]([C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][C:49]=1[C:54]([F:57])([F:56])[F:55])[C:3]([N:5]([CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]2[N:23](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[N:22]=[N:21][N:20]=2)=[CH:9][CH:8]=1)=[O:4].C(O)(=O)C.CO>C(Cl)Cl>[CH3:1][N:2]([C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][C:49]=1[C:54]([F:57])([F:56])[F:55])[C:3]([N:5]([CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]2[NH:23][N:22]=[N:21][N:20]=2)=[CH:9][CH:8]=1)=[O:4]