HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 178446315, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 1-methyl-3-pentyl-1-[2-(trifluoromethyl)phenyl]-3-[[2'(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]urea | HCID 19024452 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178446315 | HCID 178446315 | 31% |
Reaction Steps
By the procedure of Example 8, Step D, 1-methyl-3-pentyl-1-[2-(trifluoromethyl)phenyl]-3-[[2'(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]urea (from Step A) was deprotected with aqueous acetic acid. The residual oil was flash chromatographed on silica gel (elution with 3% and then 5% MeOH in CH2Cl2) to give a 31% yield of the title compound as a stiff foam, homogeneous by TLC (95:5 CH2Cl2 -MeOH); FAB-MS m/e 523 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05312820 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-6bde664c63b041b5ae1cb9666cb09e90 |
| Source note | uspto-grants-1994_05 |