Indene → Lithium, 1H-inden-1-yl-
Reaction equation
C([Li:5])CCC.CCCCCC.[CH2:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13]1>C(OCC)C>[CH-:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13]1.[Li+:5]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- -78 °C
Procedure
A 500 mL Schlenk flask is charged with diethyl ether, 225 mL, and n-butyllithium, 13.6 mL of a 2.93M solution in hexane (45 mmole). The mixture is stirred magnetically and chilled to -78° C. in a dry ice/acetone bath. Indene, 5.25 mL (45 mmole), is added to the solution which is then allowed to warm to room temperature. The solution is stirred at least 12 hours at room temperature prior to further reaction. Titration of the sample shows the reaction is complete.
Workup
- temperatureto warm to room temperature
- stirringThe solution is stirred at least 12 hours at room temperature
- customto further reaction
Sources & evidence
- ORD record
- ord-1d1e96d61f8c4da789b4fbbf9abc7a77
- Source dataset
- uspto-grants-1994_05
- Patent number
- US05312938
Reaction notes
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