Imidazole → HCID 10471173, compound

HRID 1033883Notes

Reaction equation

HRID 1033883 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Cl:24])[C:7](/[CH:10]=[CH:11]\[C:12]([O:14]CC)=[O:13])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4].N1C=CN=C1>>[CH2:1]([C:5]1[N:6]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Cl:24])[C:7](/[CH:10]=[CH:11]\[C:12]([OH:14])=[O:13])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 795ImidazoleHCID 9974942HCID 9974942, compound

Product 1

HCID 10471173HCID 10471173, compound

Procedure

The title compound was prepared according to the procedure described in Example 11 Method A by using ethyl (Z)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-propenoate in place of methyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-propenoate. The title compound had a mp 183°-184° C. The NMR was consistent with a cis or (Z) relationship of the imidazole and carboxyl groups.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-09beff74fbc84dba94d6d3c27939d822
Source dataset
uspto-grants-1994_05
Patent number
US05312828

Reaction notes

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