HCID 86747869, compound → HCID 9974054, compound

HRID 1033886Notes

Reaction equation

HRID 1033886 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:25])[C:7](/[C:10](/[CH3:17])=[CH:11]/[C:12]([O:14]CC)=[O:13])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]>C(OCC)(=O)C.CO>[CH2:1]([C:5]1[N:6]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:25])[C:7](/[C:10](/[CH3:17])=[CH:11]/[C:12]([OH:14])=[O:13])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 86747869HCID 86747869, compound

Product 1

HCID 9974054HCID 9974054, compound

Reagents, catalysts & solvents 1

HCID 21584119Ethylacetate methanolSolvent

Procedure

The title compound was prepared according to Example 1(v) by using ethyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-3-methyl-2-propenoate in place of ethyl-(E)-3-[2-n-butyl-1-{(2-chlorgphenyl)methyl}-1H-imidazol-5-yl]-2-methyl-2-propenoate. The title compound was a white solid, and was converted to the hydrochloride salt to give 82 mg (41%); mp 198°-199.5° C. (from ethyl acetate/methanol).

Workup

  1. customThe title compound was prepared
  2. customto give 82 mg (41%)

Sources & evidence

ORD record
ord-7903f81c2fa1499096d8c0904150d87b
Source dataset
uspto-grants-1994_05
Patent number
US05312828

Reaction notes

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